Pirt reduces bladder overactivity by inhibiting purinergic receptor P2X3
نویسندگان
چکیده
منابع مشابه
Sensory purinergic receptor P2X3 is elevated in burning mouth syndrome.
Recent studies show that P2X(3) may play a role in neuropathic pain, including orofacial pain. Burning mouth syndrome (BMS) is a chronic neuropathic pain condition affecting 0.6-12% of post-menopausal women in the Western world. This study evaluates, for the first time, P2X(3) immunoreactivity levels in lingual mucosa in BMS patients. Patients diagnosed with BMS (n=9) in accordance with Interna...
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BACKGROUND Diabetic neuropathy is a common neuropathy associated with paresthaesia and pain. The mechanisms underlying the painful conditions are not well understood. The aim of this study is to investigate the participation of purinergic P2X3 receptors in painful diabetic neuropathy. RESULTS Diabetes was induced by an intraperitoneal injection of streptozotocin (STZ). We showed that mechanic...
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© Translational Andrology and Urology. All rights reserved. Transl Androl Urol, 2016;5(S1) tau.amegroups.com Compared with the control group, the quantity of MDA was increased and the activities of SOD and GSH-Px were decreased in diabetic group (P<0.05) while GSPE could reverse the changes of MDA, SOD and GSH-Px. Conclusions: GSPE could ameliorate diabetic bladder dysfunction which may be asso...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2015
ISSN: 2041-1723
DOI: 10.1038/ncomms8650